Animal Models in HFpEF

To better define HFpEF clinically, patients are nowadays often clustered into phenogroups, based on their comorbidities and symptoms.

Many animal models claim to mimic HFpEF, but phenogroups are not yet regularly used to cluster them.

HFpEF animals models often lack reports of clinical symptoms of HF, therefore mainly presenting as extended models of LVDD, clinically seen as a prestate of HFpEF.

This article investigates if clinically relevant phenogroups can guide selection of animal models aiming at better defined animal research.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436760/pdf/main.pdf